Reference Library

Here you will find some key references and recent clinical research describing Nasal High Flow therapy in the neonatal and pediatric populations. 

Abboud P, Roth P, Skiles C, et al. Predictors of failure in infants with viral bronchiolitis treated with high-flow, high-humidity nasal cannula therapy. Pediatr Crit Care Med 2012;13(6):e343-9

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Arora B, Mahajan P, Zidan MA, et al. Nasopharyngeal airway pressures in bronchiolitis patients treated with high-flow nasal cannula oxygen therapy. Pediatric emergency care. 2012;28(11):1179-84.

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Bressan S, Balzani M, Krauss B, et al. High-flow nasal cannula oxygen for bronchiolitis in a pediatric ward: A pilot study. Eur J Pediatr 2013;172(12):1649-56

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Canares T, Ticker C, Garro A. Going with the flow: respiratory care in the pediatric emergency department. Rhode Island Med Jour 2014;3(97):23-6

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Chidekel A, Zhu Y, Wang J, et al. The Effects of Gas Humidification with High-Flow Nasal Cannula on Cultured Human Airway Epithelial Cells. Pulmonary Medicine. 2012.

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Collaborative Group for the Multicenter study on HHHFNC Ventilation. Efficacy and safety of heated humidified high-flow nasal cannula for prevention of extubation failure in neonates. Chinese Journal of Pediatrics. 2014; 52 (4): 271-276

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Collins C, Holberton J, Barfield C, et al. A randomized controlled trial to compare heated humidified high-flow nasal cannulae with nasal continuous positive airway pressure postextubation in premature infants. J Pediatr 2013;162(5):949-54

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De Jongh BE, Locke R, Mackley A, et al. Work of breathing indices in infants with respiratory insufficiency receiving high-flow nasal cannula and nasal continuous positive airway pressure. Journal of Perinatology. 2014;34(1):27-32.

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Frizzola M, Miller TL, Rodriguez ME, et al. High-flow nasal cannula: Impact on oxygenation and ventilation in an acute lung injury model. Pediatric pulmonology. 2011;46(1):67-74.

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Hasani A, Chapman TH, McCool D, et al. Domiciliary humidification improves lung mucociliary clearance in patients with bronchiectasis. Chronic respiratory disease. 2008;5(2):81-6.

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Hochwald O, Osiovich H. The use of high flow nasal cannulae in neonatal intensive care units: Is clinical practice consistent with the evidence? Journal of Neonatal-Perinatal Medicine 2010;3(3):187-91

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Hough JL, Shearman AD, Jardine LA, et al. Humidified high flow nasal cannulae: Current practice in Australasian nurseries, a survey. Journal of Pediatrics and Child Health 2011;48(2):106-13

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Kelly G, Simon H, Sturm J. High-flow nasal cannula use in children with respiratory distress in the emergency department: Predicting the need for subsequent intubation. Pediatr Emerg Care 2013;29(8):888-92

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Klingenberg C, Pettersen M, Hansen E, et al. Patient comfort during treatment with heated humidified high flow nasal cannulae versus nasal continuous positive airway pressure: a randomised cross-over trial. Arch Dis Child Fetal Neonatal Ed 2014;99(2):134-37

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Kubicka ZJ, Limauro J, Darnall RA. Heated, humidified high-flow nasal cannula therapy: yet another way to deliver continuous positive airway pressure?. Pediatrics. 2008;121(1):82-8.

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Kugelman A, Riskin A, Said W, et al. A randomized pilot study comparing heated humidified high-flow nasal cannulae with NIPPV for RDS. Pediatric pulmonology. 2015;50(6):576-83.

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Manley B, Owen L, Doyle L, et al. High-flow nasal cannulae in very preterm infants after extubation. N Engl J Med 2013;369(15):1425-33

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Mayfield S, Bogossian F, O'Mall.ey L, et al. High-flow nasal cannula oxygen therapy for infants with bronchiolitis: Pilot study. J Paediatr Child Health 2014;50(5):373-8

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McKiernan C, Chua L, Visintainer P, et al. High flow nasal cannulae therapy in infants with bronchiolitis. J Pediatr 2010;156(4):634-8

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Milési C, Baleine J, Matecki S, et al. Is treatment with a high flow nasal cannula effective in acute viral bronchiolitis? A physiologic study. Intensive Care Med. 2013;39:1088-1094

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Mündel T, Feng S, Tatkov S, et al. Mechanisms of nasal high flow on ventilation during wakefulness and sleep. Journal of Applied Physiology. 2013;114(8):1058-65

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Ojha S, Gridley E, Dorling J. Use of heated humidified high-flow nasal cannula oxygen in neonates: a UK wide survey. Acta Paediatrica 2012;102:249-53

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Pham TM, O'Malley L, Mayfield S, et al. The effect of high flow nasal cannula therapy on the work of breathing in infants with bronchiolitis. Pediatric pulmonology. 2015;50(7):713-20.

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Ritchie JE, Williams AB, Gerard C, et al. Evaluation of a humidified nasal high-flow oxygen system, using oxygraphy, capnography and measurement of upper airway pressures. Anaesth Intensive Care. 2011: 39 (6): 1103-10

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Roca O, Riera J, Torres F, et al. High-flow oxygen therapy in acute respiratory failure. Respiratory Care. 2010;55(4):408-13.

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Rubin S, Ghuman A, Deakers T, et al. Effort of breathing in children receiving high-flow nasal cannula. Pediatric Critical Care Medicine. 2014;15(1):1-6.

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Saslow JG, Aghai ZH, Nakhla TA, et al. Work of breathing using high-flow nasal cannula in preterm infants. Journal of Perinatology. 2006;26(8):476-80.

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Schlapbach LJ, Schaefer J, Brady A-M, et al. High-flow nasal cannula (HFNC) support in interhospital transport of critically ill children. Intensive Care Med 2014;40(4):592-9

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Sivieri EM, Gerdes JS, Abbasi S. Effect of HFNC flow rate, cannula size, and nares diameter on generated airway pressures: an in vitro study. Pediatric pulmonology. 2012;48(5):506-14.

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Spentzas T, Minarik M, Patters AB, et al. Children with respiratory distress treated with high-flow nasal cannula. Journal of intensive care medicine. 2009;24(5):323-8.

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Ten Brink F, Duke T, Evans J. High-flow nasal prong oxygen therapy or nasopharyngeal continuous positive airway pressure for children with moderate-to-severe respiratory distress? Pediatric Critical Care Medicine. 2013;14(7):e326-31.

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Testa G, Iodice F, Ricci Z, et al. Comparative evaluation of high-flow nasal cannula and conventional oxygen therapy in paediatric cardiac surgical patients: a randomized controlled trial. Interactive CardioVascular and Thoracic Surgery. 2014: 1-6

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Wilkinson DJ, Andersen CC, Smith K, et al. Pharyngeal pressure with high-flow nasal cannulae in premature infants. Journal of Perinatology. 2008;28(1):42-7.

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Wing R, James C, Maranda L, et al. Use of high-flow nasal cannula support in the emergency department reduces the need for intubation in pediatric acute respiratory insufficiency. Pediatr Emerg Care 2012;28(11):1117-23

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Yoder B, Stoddard R, Li M, et al. Heated, humidified high-flow nasal cannula versus nasal CPAP for respiratory support in neonates. Pediatrics 2013;131(5):1482-90

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