Mechanisms of Action

The following mechanisms describe how Nasal High Flow therapy with Optiflow™ Junior works.

How does Nasal High Flow therapy work?

Reduction of Dead Space

Nasal High Flow therapy enhances upper airway clearance and reduces rebreathing of CO2, which increases alveolar ventilation1,2.

 

References

  1. Mündel T, Feng S, Tatkov S, et al. Mechanisms of nasal high flow on ventilation during wakefulness and sleep. Journal of Applied Physiology. 2013;114(8):1058-65
  2. Frizzola M, Miller TL, Rodriguez ME, et al. High‐flow nasal cannula: Impact on oxygenation and ventilation in an acute lung injury model. Pediatric pulmonology. 2011;46(1):67-74.

Dynamic Positive Airway Pressure

Breath and flow dependent positive airway pressure promotes slow and deep breathing1,2,3.

 

References

  1. Mündel T, Feng S, Tatkov S, et al. Mechanisms of nasal high flow on ventilation during wakefulness and sleep. Journal of Applied Physiology. 2013;114(8):1058-65
  2. Wilkinson DJ, Andersen CC, Smith K, et al. Pharyngeal pressure with high-flow nasal cannulae in premature infants. Journal of Perinatology. 2008;28(1):42-7.
  3. Arora B, Mahajan P, Zidan MA, et al. Nasopharyngeal airway pressures in bronchiolitis patients treated with high-flow nasal cannula oxygen therapy. Pediatric emergency care. 2012;28(11):1179-84.

Supplemental Oxygen

Optiflow Junior can be used to deliver humidified room air or accurately deliver blended, humidified oxygen1.

References

  1. Ritchie JE, Williams AB, Gerard C, et al. Evaluation of a humidified nasal high-flow oxygen system, using oxygraphy, capnography and measurement of upper airway pressures. Anaesth Intensive Care. 2011: 39 (6): 1103-10

Optimal Humidity

High flows can be delivered comfortably and optimal humidification improves mucocilliary transport and mucus clearance1,2,3.

Learn More About Optimal Humidity

      

 

 

 

References

  1. Hasani A, Chapman TH, McCool D, et al. Domiciliary humidification improves lung mucociliary clearance in patients with bronchiectasis. Chronic respiratory disease. 2008;5(2):81-6.
  2. Roca O, Riera J, Torres F, et al. High-flow oxygen therapy in acute respiratory failure. Respiratory Care. 2010;55(4):408-13.
  3. Chidekel A, Zhu Y, Wang J, et al. The Effects of Gas Humidification with High-Flow Nasal Cannula on Cultured Human Airway Epithelial Cells. Pulmonary Medicine. 2012.

Ease of Use

Optiflow Junior is an open system that enhances patient comfort1,2.

      

 

References

  1. Roca O, Riera J, Torres F, et al. High-flow oxygen therapy in acute respiratory failure. Respiratory Care. 2010;55(4):408-13.
  2. Spentzas T, Minarik M, Patters AB, et al. Children with respiratory distress treated with high-flow nasal cannula. Journal of intensive care medicine. 2009;24(5):323-8.

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