A reduction in SSI rate from 12.1% to 4.7% with the use of warm, humidified CO2 during laparoscopic colorectal surgery is indicated in present clinical evidence.9
Subcutaneous changes in oxygen tension predict the incidence of Surgical Site Infections. The better oxygenated the wound, the less chance of getting an infection.13
Research in rodent models shows that the average increase in pO2 (tissue partial pressure of oxygen) with warm, humidified CO2 is 29.8 mmHg14
An increase in pO2 from base line greater than 25 mmHg is clinically significant
An increase of 25 mmHg in pO2 is shown to predict a 30% drop in SSI rate13
A 40-50% fall in pO2 is highly predictive of anastomotic leakage15
There is an immediate decrease in pO2 when warm, humidified CO2 is stopped. The graph on the right shows the change in tissue oxygenation when exposed to ambient air or humidified CO2 in a rodent model. The shaded area demonstrates when warm, humidified insufflation was in use.
Graph reproduced from Marshall et al., 201514